Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans
| Autor: | Dominic-Luc Webb, John E. Blundell, Catherine Gibbons, Graham Finlayson, Phillipa Caudwell, Erik Näslund, Per M. Hellström |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Fysiologi High carbohydrate Physiology media_common.quotation_subject 030209 endocrinology & metabolism Context (language use) Satiation Overweight Diet High-Fat Biochemistry Sincalide 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Internal medicine Dietary Carbohydrates medicine High fat Humans Insulin Obesity media_common 2. Zero hunger Meal Cross-Over Studies 030109 nutrition & dietetics Appetite Regulation digestive oral and skin physiology Appetite Middle Aged Postprandial Period 16. Peace & justice Postprandial Research centre CCK Satiety Eating behaviour Female medicine.symptom Psychology |
| Zdroj: | Peptides. 77:3-8 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/j.peptides.2015.09.010 |
| Popis: | Context CCK is understood to play a major role in appetite regulation. Difficulties in measuring CCK have limited the potential to assess its profile in relation to food-induced satiety. Improvements in methodology and progress in theoretical understanding of satiety/satiation make it timely for this to be revisited. Objective First, examine how physiologically relevant postprandial CCK8/33(s) profiles are influenced by fat (HF) or carbohydrate (HCHO) meals. Second, to examine relationships between postprandial CCK and profiles of satiety (hunger/fullness) and satiation (meal size). Participants and design Sixteen overweight/obese adults (11 females/5 males) participated in a randomised-crossover study (46 years, 29.8 kg/m2) in a university research centre. Plasma was collected preprandially and for 180 min postprandially. Simultaneously, ratings of hunger/fullness were tracked for 180 min before an ad libitum lunch was provided. Results CCK8/33(s) levels increased more rapidly and reached a higher peak following HF compared to HCHO breakfast (F(1,15) = 14.737, p < 0.01). Profiles of hunger/fullness did not differ between conditions (F(1,15) = 0.505, p = 0.488; F(1,15) = 2.277, p = 0.152). There was no difference in energy intake from the ad libitum meal (HF-3958 versus HCHO-3925 kJ; t(14) = 0.201, p = 0.844). CCK8/33(s) profiles were not associated with subjective appetite during early and late phases of satiety; nor was there an association between CCK8/33(s) and meal size. Conclusions These results demonstrate CCK levels were higher after HF meal compared to HCHO isocaloric meal. There was no association between CCK levels and intensity of satiety, or with meal size. Under these circumstances, CCK does not appear to play a unique independent role in satiety/satiation. CCK probably acts in conjunction with other peptides and the action of the stomach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect