Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions

Autor:	Roberto del Río-Rodríguez, Matthew T. Westwood, Marina Sicignano, Martin Juhl, Jose A. Fernández-Salas, José Alemán, Andrew D. Smith
Přispěvatelé:	University of St Andrews. School of Chemistry
Rok vydání:	2022
Předmět:	MCC Lactams Thiourea Metals and Alloys Stereoisomerism DAS General Chemistry QD Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Materials Chemistry Ceramics and Composites QD
Zdroj:	Chemical Communications. 58:7277-7280
ISSN:	1364-548X 1359-7345 2018-0950
DOI:	10.1039/d2cc02432b
Popis:	Financial support was provided by the Spanish Government (RTI2018-095038-B-I00), “Comunidad de Madrid” for European Structural Funds (S2018/NMT-4367) and proyectos sinergicos I+D (Y2020/NMT-6469). J. A. F.-S. thanks the Spanish Government for a Ramón y Cajal contract. The research leading to these results has received funding from the EaSI-CAT centre for Doctoral Training (M.T.W) and Carlsberg Foundation (M.J.). The photocatalytic generation of α-amino radicals is combined with chiral isothiourea derived α,β-unsaturated acyl ammonium intermediates. The reaction proceeds via a [3+2] radical-polar crossover mechanism to generate γ-lactams in good yields and enantioselectivities. The enantioselective radical conjugate addition was carried out under batch and flow conditions. Publisher PDF
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea663aa6fc640e9a3155c0b3259da03 https://doi.org/10.1039/d2cc02432b Zobrazit plný text záznamu