5-Lipoxygenase inhibition by acetyl-11-keto-β-boswellic acid (AKBA) by a novel mechanism
| Autor: | Hermann P. T. Ammon, Hasan Safayhi, E.-R. Sailer |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
chemistry.chemical_classification biology Stereochemistry Pharmaceutical Science Substrate (chemistry) biology.organism_classification chemistry.chemical_compound Enzyme Complementary and alternative medicine Biochemistry chemistry Triterpene Drug Discovery Arachidonate 5-lipoxygenase biology.protein Molecular Medicine Boswellia serrata Boswellic acid Binding site Pentacyclic Triterpenes |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 3(1) |
| ISSN: | 0944-7113 |
| Popis: | Acetyl-11-keto-β-boswellic acid (AKAB) from Boswellia serrata and B. carterii acts directly on purified 5-lipoxygenase of human blood leukocytes at a selective site for pentacyclic triterpenes that is different from the arachidonate substrate binding site. The pentacyclic triterpene ring is crucial for binding to the enzyme, whereas functional groups (11-keto function in addition to a hydrophilic group on C 4 of ring A) are essential for the 5-lipoxygenase activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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