Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristics
| Autor: | Naveen Ahuja, Sonia Pahuja, Rishi Kapil, Bhupinder Singh |
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| Rok vydání: | 2009 |
| Předmět: |
Central composite design
Swine Chemistry Pharmaceutical Vasodilator Agents Bioadhesive Acrylic Resins Administration Oral Pharmaceutical Science In Vitro Techniques Methylcellulose Pharmacology chemistry.chemical_compound Hypromellose Derivatives medicine Animals Response surface methodology Drug Carriers Chemistry Adhesiveness General Medicine Hydralazine Controlled release Gastric Mucosa Hydralazine Hydrochloride Delayed-Action Preparations Methyl cellulose Drug delivery Tablets Biomedical engineering medicine.drug |
| Zdroj: | Acta Pharmaceutica. 59:1-13 |
| ISSN: | 1846-9558 1330-0075 |
| DOI: | 10.2478/v10007-009-0005-z |
| Popis: | Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristicsThe current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of theirin vitrodrug release profile andex vivobioadhesion against porcine gastric mucosa. A 32central composite design was employed to systematically optimize the drug delivery formulations containing two polymers,viz., carbomer and hydroxypropyl methyl cellulose. Response surface plots were drawn and optimum formulations were selected by brute force searches. Validation of the formulation optimization study indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of hydralazine with excellent bioadhesive and controlled release characteristics. |
| Databáze: | OpenAIRE |
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