Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

Autor:	Shailaja Myadaraboina, Manjula Alla, Venkateshwarlu Saddanapu, Anthony Addlagatta, Vittal Rao Bommena
Rok vydání:	2010
Předmět:	Pharmacology Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Pyrazine Chemistry Stereochemistry Organic Chemistry Imidazoles Antineoplastic Agents General Medicine Nuclear magnetic resonance spectroscopy Chemical synthesis In vitro Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Cell Line Tumor Pyrazines Drug Discovery Electrophile Humans Structure–activity relationship Drug Screening Assays Antitumor Cancer cell lines Cytotoxicity
Zdroj:	European Journal of Medicinal Chemistry. 45:5208-5216
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2010.08.035
Popis:	Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing α-aminopyrazines with α-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea496314e1bbf06254900a5f5afe42a https://doi.org/10.1016/j.ejmech.2010.08.035 Zobrazit plný text záznamu Full Text from ScienceDirect