Allelotyping of gastrointestinal nasal-type NK/T-cell lymphoma
| Autor: | John Chow, Maxim Wan, Kenny I.K. Lei, Wing Y. Chan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent Nose Neoplasms Loss of Heterozygosity Biology Lymphoma T-Cell Polymerase Chain Reaction Nose neoplasm Loss of heterozygosity medicine Humans T-cell lymphoma Alleles In Situ Hybridization Gastrointestinal Neoplasms Gastrointestinal tract Autosome Hematology Middle Aged medicine.disease Lymphoma Killer Cells Natural Oncology Allelic Imbalance Cancer research Female Microsatellite Repeats Comparative genomic hybridization |
| Zdroj: | Leukemia Research. 28:339-343 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2003.08.004 |
| Popis: | Nasal-type natural killer/T-cell lymphoma (NKL) is a rare but distinct malignancy that often involves the mid-facial region and the gastrointestinal tract. This study is the first genome-wide allelotyping analysis on this rare lymphoma. We applied 382 microsatellite markers covering loci which spanned 22 autosomes to screen for allelic imbalances (AI) in six intestinal NKL. The most common chromosomal regions of allelic imbalances were found in 11p, 9q and 13q. Novel spots of allelic losses spots found at 2p21, 2q37.22, 18p11.21 and 18q12.1. In spite of presence of a few recurrent loci of imbalances, the allelotyping results show that NKL is heterogeneous. |
| Databáze: | OpenAIRE |
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