Male-sterile phenotype of the neurological mouse mutant weaver
| Autor: | Susan M. W. Harrison, Suzanne Roffler-Tarlov |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum Genotype Sterility Spermiogenesis Genes Recessive Biology Testicle Mice Mice Neurologic Mutants Internal medicine Testis medicine Animals Spermatogenesis Infertility Male Epididymis Age Factors Brain Cell Differentiation Seminiferous Tubules Sperm Epithelium Mice Inbred C57BL medicine.anatomical_structure Endocrinology Phenotype Mice Inbred CBA Developmental Biology |
| Zdroj: | Developmental dynamics : an official publication of the American Association of Anatomists. 200(1) |
| ISSN: | 1058-8388 |
| Popis: | The autosomal recessive murine mutation weauer (wu) affects postnatal differenti- ation in at least three neuronal populations in the brain: dopamine-containing neurons in the mid- brain, and granule and Purkinje cells in the cere- bellum. Neuronal populations vulnerable to the actions of weaver die in the midst of development. In addition, homozygous weaver males are sterile. We show by a histological analysis of epididy- mides and testes that the cause of male sterility in weaver is lack of sperm. The epididymides of the adult weaver mice examined were devoid of sperm, and few seminiferous tubules in the adult weaver's testes contained elongated spermatids. Most tubules were marked by moderate to severe degeneration of the seminiferous epithelium. A developmental study showed that the mutant phe- notype emerged after the third postnatal week. By postnatal day 28, the development of weaver sperm lagged behind that of the wild-type and some seminiferous tubules contained degenerat- ing germ cells. By postnatal day 35, terminal dif- ferentiation of spermatids appeared to be ar- rested in many tubules and degeneration of the seminiferous epithelium was widespread. The het- erozygotes were unaffected at all ages sampled. We conclude that the normal allele at the weaver locus is necessary for spermiogenesis and the maintenance of spermatogenesis. 0 1994 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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