Cornu Cervi Pantotrichum Supplementation Improves Exercise Performance and Protects against Physical Fatigue in Mice

Autor: Nai Wen Kan, Chi Chang Huang, Hui Ling Chao, Yi-Ming Chen, Mei-Chich Hsu, Chin Shan Ho
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Blood Glucose
Male
Pharmaceutical Science
Administration
Oral
Antlers
Traditional Chinese medicine
Analytical Chemistry
Grip strength
chemistry.chemical_compound
Mice
Stimulants
Historical
immune system diseases
Drug Discovery
Exercise performance
skin and connective tissue diseases
Fatigue
Mice
Inbred ICR
deer antler
grip strength
antifatigue
biology
medicine.anatomical_structure
Physical Fatigue
Chemistry (miscellaneous)
Molecular Medicine
musculoskeletal diseases
medicine.medical_specialty
Physical Exertion
Complex Mixtures
Protective Agents
Article
lcsh:QD241-441
lcsh:Organic chemistry
Ammonia
Internal medicine
Physical Conditioning
Animal
medicine
Animals
Lactic Acid
Muscle Strength
Physical and Theoretical Chemistry
Muscle
Skeletal
Swimming
business.industry
Deer
Organic Chemistry
Skeletal muscle
Alkaline Phosphatase
Endocrinology
chemistry
biology.protein
Uric acid
Creatine kinase
Forelimb
business
Zdroj: Molecules; Volume 19; Issue 4; Pages: 4669-4680
Molecules
Molecules, Vol 19, Iss 4, Pp 4669-4680 (2014)
ISSN: 1420-3049
DOI: 10.3390/molecules19044669
Popis: Cornu cervi pantotrichum (CCP) is a well-known yang-invigorating agent used in traditional Chinese medicine that can nourish the blood, tonify qi, and invigorate bones and tendons with multifunctional bioactivities. However, evidence on the effects of CCP on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of ethanolic extract from CCP on ergogenic and antifatigue functions following a physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered CCP for 14 days at 0, 2054, and 4108 mg/kg/day, and were respectively designated as the vehicle, CCP-1X, and CCP-2X groups. The physical performance and antifatigue function were evaluated using forelimb grip strength and exhaustive swimming time as well as serum levels of lactate, ammonia, glucose, and creatine kinase after a 15-min swimming exercise. The results indicated that CCP-1X supplementation significantly improved grip strength; reduced fatigue-associated biochemical indices, including lactate and ammonia levels; and ameliorated skeletal muscle injury induced by acute exercise challenge. A trend analysis revealed that CCP supplementation significantly increased grip strength and dose-dependently reduced serum alkaline phosphatase, uric acid, triacylglycerol, and glucose levels in healthy mice. Therefore, CCP is a potential agent with an antifatigue pharmacological effect.
Databáze: OpenAIRE
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