Fabrication of Tizanidine Loaded Patches Using Flaxseed Oil and Coriander Oil as a Penetration Enhancer for Transdermal Delivery

Autor:	Abul Kalam Azad, Neeraj Kumar Fuloria, Mahendran Sekar, Dhanalekshmi Unnikrishnan Meenakshi, Sajid Raza, Yuan Seng Wu, Asif Nawaz, Vetriselvan Subramaniyan, Shivkanya Fuloria, Muhammad Safdar, Kathiresan V. Sathasivam, Muhammad Akhlaq, Mireia Mallandrich Miret
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Polymers and Plastics Organic chemistry Medicació transdèrmica flaxseed oil Article Coriander Oil Chitosan chemistry.chemical_compound QD241-441 Ethyl cellulose Pharmacokinetics medicine tizanidine Transdermal Chromatography Polyvinylpyrrolidone Chemistry General Chemistry Permeation Transdermal medication coriander oil ethyl cellulose polyvinyl pyrrolidone patches Drug delivery systems Sistemes d'alliberament de medicaments Tizanidine medicine.drug
Zdroj:	Polymers Polymers, Vol 13, Iss 4217, p 4217 (2021) Polymers; Volume 13; Issue 23; Pages: 4217 Dipòsit Digital de la UB Universidad de Barcelona
ISSN:	2073-4360
Popis:	Transdermal drug delivery is important to maintain plasma drug concentrations for therapeutic efficacy. The current study reports the design, formulation, and evaluation of tizanidine transdermal patches formulated using chitosan and thiolated chitosan, ethyl cellulose (EC), polyvinylpyrrolidone (PVP), and Eudragit RL100 in different ratios. The tizanidine patches were formulated using flaxseed oil and coriander oil in the concentrations of 1% v/w, 2% v/w, 3% v/w, 4% v/w, 5% v/w, and 10% v/w. The patches were subjected to characterization of physicochemical property (thickness, weight uniformity, drug content, efficiency, percentage moisture uptake/loss), in vitro drug release and drug permeation, skin irritation, in vivo application, pharmacokinetics analysis, and stability studies. The results indicate that the interaction of thiolated chitosan with the negative charges of the skin opens the tight junctions of the skin, whereas flaxseed and coriander oils change the conformational domain of the skin. The novelty of this study is in the use of flaxseed and coriander oils as skin permeation enhancers for the formulation of tizanidine transdermal patches. The formulations follow non-Fickian drug release kinetics. The FTZNE23, FTZNE36 and FTZNE54, with 5% v/w flaxseed oil loaded formulations, exhibited higher flux through rabbit skin compared with FTZNE30, FTZNE35, FTZNE42, and FTZNE47, formulations loaded with 10% v/w coriander oil. The study concludes that flaxseed oil is a better choice for formulating tizanidine patches, offering optimal plasma concentration and therapeutic efficacy, and recommends the use of flaxseed and coriander oil based patches as a novel transdermal delivery system for tizanidine and related classes of drugs.
Databáze:	OpenAIRE
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