Safety and efficacy of transcatheter arterial chemoemboliazation in the real-life management of unresectable hepatocellular carcinoma
| Autor: | George N. Dalekos, Kostantinos Tepetes, Kalliopi Zachou, Dimitrios Filippiadis, George K. Koukoulis, Christos Rountas, Nikolaos K. Gatselis, Ioannis Fezoulidis, Argyro Mazioti |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Liver Cirrhosis medicine.medical_specialty Multivariate analysis Carcinoma Hepatocellular Alcohol abuse Lesion Internal medicine medicine Carcinoma Chemoembolization Therapeutic Hepatology business.industry Proportional hazards model Brief Report Hepatitis C medicine.disease digestive system diseases Surgery Kowsar Infectious Diseases Hepatocellular carcinoma medicine.symptom business Hepatitis B Virus |
| Zdroj: | Hepatitis Monthly |
| ISSN: | 1735-143X |
| Popis: | Background Trans-arterial chemoembolization (TACE) is associated with better survival in BCLC-stage B patients with hepatocellular carcinoma (HCC) and Child-Pugh A whereas in Child-Pugh B there is no definite evidence of benefit. Objectives To assess the safety and efficacy of TACE during routine clinical practice in a consecutive Greek cohort of patients with unrespectable HCC. Patients and Methods Seventy one patients enrolled for this study (mean follow-up:24.6 months). 100 mg cisplatin, 50 mg doxorubicin and 10 ml lipiodol as well as embolic materials were used. CT-scans and blood tests were obtained prior and post-TACE. Kaplan–Meier method and Cox proportional hazard model were used to evaluate survival and factors affecting survival. Results Survival at 1-year, 2-years, 3-years and 5-years was 73.2%, 45.4%, 33.2% and 14.9% respectively. Procedure-related mortality was 1.4%. Multivariate analysis showed lesion diameter, Child-Pugh classification, alcohol abuse, tumor response and AFP prior TACE as independent prognostic factors of survival. Patients diagnosed during surveillance had significantly better survival rates compared to those diagnosed after development of symptoms (HR = 0.58, 95%CI: 0.33-1.01, P < 0.05). Conclusions TACE is safe and efficient for unrespectable HCC. Alcohol abuse, tumor burden, response criteria, Child-Pugh and AFP prior to the session were identified as independent predictors of survival whereas, adherence to surveillance programs resulted in significantly better survival in these patients. |
| Databáze: | OpenAIRE |
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