Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis
| Autor: | T Uutela, Hannu Kautiainen, Arja Häkkinen |
|---|---|
| Přispěvatelé: | Clinicum, Department of General Practice and Primary Health Care |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
nivelreuma
rheumatoid arthritis Male INACTIVITY Arthritis lcsh:Medicine Muscle Proteins Comorbidity Biochemistry Severity of Illness Index Arthritis Rheumatoid Grip strength 0302 clinical medicine Risk Factors STRENGTH CACHEXIA Medicine and Health Sciences CRITERIA Public and Occupational Health 030212 general & internal medicine lcsh:Science Musculoskeletal System INDEX Pain Measurement 2. Zero hunger Multidisciplinary Muscles WOMEN ta3141 Muscle Analysis Middle Aged Sports Science 3. Good health Bioassays and Physiological Analysis Rheumatoid arthritis Strength Training Female BONE-MINERAL DENSITY Anatomy lihaskunto Research Article medicine.medical_specialty muscle fitness Strength training HEALTHY CONTROLS Immunology Rheumatoid Arthritis Research and Analysis Methods Autoimmune Diseases 03 medical and health sciences Rheumatology Internal medicine Hand strength medicine Rheumatoid factor Humans Muscle Strength Risk factor Sports and Exercise Medicine Muscle Skeletal Exercise 030203 arthritis & rheumatology business.industry lcsh:R ENERGY-EXPENDITURE Beck Depression Inventory Biology and Life Sciences Proteins Physical Activity medicine.disease Joints (Anatomy) PHYSICAL-ACTIVITY Cross-Sectional Studies Skeletal Muscles Physical Fitness 3121 General medicine internal medicine and other clinical medicine muscle strength Physical Endurance lcsh:Q Clinical Immunology Clinical Medicine business lihasvoima |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 4, p e0194917 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Objectives Increasing evidence suggests that inflammation has a detrimental effect on muscle strength. Our objective was to analyse the association between muscle performance and different disease activity levels in patients with rheumatoid arthritis (RA). Method A total of 199 consecutive outpatients were subject to cross-sectional assessment. Measurements of grip strength, endurance of the upper and lower limbs and trunk strength were combined as a muscle performance composite score (MPCS), using a standardised method. The disease activity for 28 joints (DAS28), radiographs of small joints (Larsen score), rheumatoid factor, body mass index (BMI), comorbidities and anti-rheumatic drugs were verified. Patients’ questionnaires included sociodemographic information, pain level, global disease activity, the Beck Depression Inventory, the mental and physical component scores of Short Form-36 and physical activity level. Results Of the 199 patients, 36%, 17% and 47% patients had remission, low/moderate and high DAS28, respectively. The patients in remission had significantly shorter disease duration, better parameters in terms of pain, physician’s assessment, Larsen, Beck or physical component score of Short Form-36, and they were more physically active than other patients. After adjustments for age, sex, RA duration, radiographs and BMI, the decreasing MPCS associated linearly with the increasing DAS28 activity levels (linearity, P |
| Databáze: | OpenAIRE |
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