Sperm Proteomics: Road to Male Fertility and Contraception
| Autor: | Myung-Geol Pang, Woo-Sung Kwon, Saidur Rahman, June-Sub Lee |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
endocrine system
education.field_of_study lcsh:RC648-665 urogenital system Endocrine and Autonomic Systems Endocrinology Diabetes and Metabolism Cellular differentiation media_common.quotation_subject Population Fertility Review Article Biology Proteomics lcsh:Diseases of the endocrine glands. Clinical endocrinology Sperm Cell biology Andrology Endocrinology Membrane protein Drug development Proteome education media_common |
| Zdroj: | International Journal of Endocrinology International Journal of Endocrinology, Vol 2013 (2013) |
| ISSN: | 1687-8345 1687-8337 |
| DOI: | 10.1155/2013/360986 |
| Popis: | Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very suitable for proteomic studies. Recently, the application of proteomic approaches such as the two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, and differential in-gel electrophoresis has identified several sperm-specific proteins. These findings have provided a further understanding of protein functions involved in different sperm processes as well as of the differentiation of normal state from an abnormal one. In addition, studies on the sperm proteome have demonstrated the importance of spermatozoal posttranslational modifications and their ability to induce physiological changes responsible for fertilization. Large-scale proteomic studies to identify hundreds to thousands of sperm proteins will ultimately result in the development of novel biomarkers that may help to detect fertility, the state of complete contraception, and beyond. Eventually, these protein biomarkers will allow for a better diagnosis of sperm dysfunctions and aid in drug development. This paper reviews the recent scientific publications available from the PubMed database to address sperm proteomics and its potential application to characterize male fertility and contraception. |
| Databáze: | OpenAIRE |
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