The relation of increased uterine artery blood flow resistance and impaired trophoblast invasion in pre-eclamptic pregnancies
| Autor: | E. Zemheri, Nese Yucel, Selen Sezginsoy, Murat Naki, Fahrettin Kanadikirik, Sedat Tomruk, Kadir Güzin, Yildiz Ayhan Tuncay |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Spiral artery Biopsy Population Ultrasonography Prenatal Preeclampsia Pre-Eclampsia Pregnancy Placenta medicine.artery Decidua medicine Humans Uterine artery education reproductive and urinary physiology Gynecology education.field_of_study Obstetrics business.industry Uterus Obstetrics and Gynecology Trophoblast Ultrasonography Doppler General Medicine medicine.disease Trophoblasts medicine.anatomical_structure Vascular resistance Arterial blood Female Vascular Resistance business Blood Flow Velocity |
| Zdroj: | Archives of Gynecology and Obstetrics. 272:283-288 |
| ISSN: | 1432-0711 0932-0067 |
| DOI: | 10.1007/s00404-005-0005-2 |
| Popis: | To assess the association between histopathologically confirmed vascular abnormalities developed during pre-eclampsia and abnormal arterial blood flows recorded during Doppler sonographies.From pregnant women who attended our clinic between 01/03/2002 and 01/07/2002, a detailed medical history was obtained and routine biochemical blood tests, fetal ultrasonography and UA Doppler scans were performed. In addition, from pre-eclamptic and normal pregnant women who underwent cesarean sections, placental bed biopsies were taken. Thirty two pre-eclamptic [12 mild, 20 severe cases according to American College of Obstetricians and Gynecologists (ACOG) criteria] cases and as a control group 20 normal pregnancies were included in the study. In our study trophoblast invasion into decidual spiral arteries was observed in 75% of mild (9/12), and 55% of severe (11/20) pre-eclampsias. In the control group all the cases demonstrated trophoblast invasion in decidual spiral arteries. Trophoblast invasion in myometrial spiral arteries was noted in 50% (6/12) of mild and 25% (5/20) of severe pre-eclamptic pregnancies. It was seen in 16 cases out of 20 (80%) pregnancies. In the control group, decidual spiral artery invasion manifests significant differences (P0.01) among groups studied. Invasion in decidual spiral arteries was seen in all normal pregnancies of the control group. There is not any significant difference between mild and severely pre-eclamptic groups (P0.05).Doppler ultrasonography is not only a non-invasive method for evaluating fetal status in pre-eclamptic pregnancies, but it also correlates with partial trophoblastic invasion in spiral arteries, which contributes to the pathophysiologic mechanisms involved in pre-eclampsia. |
| Databáze: | OpenAIRE |
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