Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians
| Autor: | Graham A. Hitman, Michael F. McDermott, David Curtis, A. Ramachandran, Chamukuttan Snehalatha, Barbara J. Boucher, B W Ogunkolade, Ebun Aganna |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype endocrine system diseases TaqI Endocrinology Diabetes and Metabolism India Biology Polymerase Chain Reaction Calcitriol receptor Linkage Disequilibrium chemistry.chemical_compound Internal medicine Internal Medicine medicine Vitamin D and neurology Genetic predisposition Humans Family Age of Onset Allele Child Allele frequency Alleles Genetics Chromosomes Human Pair 12 Haplotype Infant nutritional and metabolic diseases Diabetes Mellitus Type 1 Endocrinology Haplotypes chemistry Child Preschool Receptors Calcitriol Female Disease Susceptibility Polymorphism Restriction Fragment Length |
| Zdroj: | Diabetologia. 40:971-975 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | Vitamin D has important immunomodulatory properties and prevents development of diabetes mellitus in an animal model of insulin-dependent diabetes (IDDM). We have studied the vitamin D receptor locus as a candidate for genetic susceptibility to IDDM in Southern Indian families. We found evidence for an association of one particular vitamin D receptor allele with IDDM susceptibility in this community. Ninety-three South Indian families consisting of available parents and an affected offspring were genotyped for three vitamin D receptor polymorphisms using the restriction enzymes TaqI, ApaI and BsmI as well as an adjacent microsatellite located to 12q14 (D12S85). Transmission disequilibrium testing analysis was used to assess preferential transmission of polymorphic markers and haplotypes with IDDM. There was significant excess transmission of vitamin D receptor alleles containing the BsmI restriction site to affected offspring in these families (p = 0.016). No association was found between D12S85 and IDDM. This study suggests that a polymorphism within or close to the vitamin D receptor gene may modify susceptibility to IDDM in this ethnic group. [Diabetologia (1997) 40: 971–975] |
| Databáze: | OpenAIRE |
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