Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
| Autor: | Enrique Nicolás García, Ofelia Acosta, Luciana Andrea Cholich, Eduardo Juan Gimeno, María Victoria Aguirre, Elvio Ríos |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Guinea Pigs Physiology Spleen Toxicology Pathology and Forensic Medicine Guinea pig Otras Ciencias Veterinarias GUINEA PIG LYMPH NODES SPLEEN medicine Animals ANAEMIA Ipomoea carnea biology IPOMOEA CARNEA Plant Extracts Ciencias Veterinarias BONE MARROW Cell Biology General Medicine biology.organism_classification Pathophysiology Hematopoiesis Plant Leaves Haematopoiesis medicine.anatomical_structure CIENCIAS AGRÍCOLAS Immunology Microscopy Electron Scanning Lymph Bone marrow Ipomoea Convolvulaceae |
| Zdroj: | Experimental and Toxicologic Pathology, 2015, vol. 67, no. 10, p. 483-490. Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) Universidad Nacional del Nordeste instacron:UNNE |
| ISSN: | 1618-1433 |
| Popis: | Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity of I. carnea in a guinea pig model through its effect on hematopoiesis in a time course study of 40 days. Experimental poisoning was achieved by feeding animals with "small balls" prepared with milled leaves of I. carnea mixed with commercial crushed pellets for rodents. Hematologic and biochemical parameters, bone marrow and spleencellularities, histopathologic evaluations and lectin-histochemistrywere performed during the scheduled time of the study. The treatment with "small balls" caused significant changes in the weight of spleen, a notable decrease in peripheral red blood cells, and concomitantwith morphological and histopathologicalalterationsin hematopoietic tissues. Overall, the present study suggested that 20 days ofthis treatmentcouldbe enough to develop bone marrow hypoplasia and vacuolation of white cells of spleen, blood and lymph nodes with a transient erythropoietic contribution of the splenic niche. Moreover, this work provides a cheap and simple method for detecting preclinical cases of intoxication by I. carnea in livestock. Fil: García, Enrique N.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Aguirre, María V.. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rios, Elvio E.. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina |
| Databáze: | OpenAIRE |
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