LRRK2 N551K and R1398H variants are protective in Malays and Chinese in Malaysia: A case–control association study for Parkinson's disease

Autor: Chong Tin Tan, Ai Huey Tan, Gaik Bee Eow, Azlina Ahmad Annuar, Zariah Abdul Aziz, Shanthi Viswanathan, Shen-Yang Lim, Aroma Agape Gopalai, Yi Zhao, Thien Thien Lim, Soo Kun Lim, Huihua Li, Jia Lun Lim, Mohamed Ibrahim Norlinah, Eng-King Tan, Santhi Datuk Puvanarajah
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecular Genetics & Genomic Medicine, Vol 7, Iss 11, Pp n/a-n/a (2019)
Molecular Genetics & Genomic Medicine
ISSN: 2324-9269
Popis: Background The LRRK2 gene is associated with Parkinson's disease (PD) as a number of mutations within the gene have been shown to be susceptibility factors. Studies on various global populations have determined that mutations such as G2019S, G2385R, and R1628P in LRRK2 increase the risk of developing PD while the N551K‐R1398H haplotype is associated with conferring protection against developing PD. Here we report a study looking at the N551K and R1398H variants for the first time in the Malaysian population. Methods Cases (523) which conformed to the United Kingdom PD Brain Bank Criteria for PD were recruited through trained neurologists and age‐ and ethnically matched controls (491) were individuals free of any neurological disorder. The N551K and R1398H mutations were genotyped using the Taqman SNP genotyping assay. Results A significant protective association for N551K was found in those of Malay ancestry, with a protective trend seen for R1398H. A meta‐analysis of Chinese individuals in this cohort with other published cohorts of Chinese ancestry indicated a significant protective role for N551K and R1398H. Conclusion This study reports that the N551K‐R1398H haplotype is also relevant to the Malaysian population, with a significant protective effect found in those of Malay and Chinese ancestries.
Databáze: OpenAIRE
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