EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma

Autor: Hao Su, Ying Gui, Gang Chen, Guangzhi Zhu, Xiaoguang Liu, Tao Peng, Zengnan Mo, Xue Qin, Zili Lu, Wei Qin, Long Yu, Zhengtao Liu, Le-Qun Li, Xiwen Liao, Zhiwei Chen, Chuangye Han, Zhi-Ming Liu, Sicong Lu
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Oncology
Genome-wide association study
Kaplan-Meier Estimate
medicine.disease_cause
Linkage Disequilibrium
Epidermal growth factor receptor
Principal Component Analysis
Multidisciplinary
biology
Liver Neoplasms
Microfilament Proteins
Nuclear Proteins
Middle Aged
Hepatitis B
ErbB Receptors
Gene Expression Regulation
Neoplastic
Treatment Outcome
Hepatocellular carcinoma
Female
Adult
Cyclin-Dependent Kinase Inhibitor p21
Quality Control
Hepatitis B virus
medicine.medical_specialty
Carcinoma
Hepatocellular
Genotype
Nerve Tissue Proteins
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Article
03 medical and health sciences
Internal medicine
Biomarkers
Tumor
medicine
Carcinoma
Humans
RNA
Messenger
Haplotype
Genetic Variation
medicine.disease
030104 developmental biology
Haplotypes
Cancer research
biology.protein
Tumor Suppressor Protein p53
Genome-Wide Association Study
Zdroj: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/srep31237
Popis: This study was to explore the association between gene variants and p21 expression and investigate the TP53-independent p21 regulation in hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) patients from Guangxi by genome-wide association study. 426 HBV-related HCC patients were enrolled. Results showed that, after quality control, a total of 21,643 SNPs were identified in 107 p21 positive and 298 p21 negative patients. The variants of epidermal growth factor receptor (EGFR; rs2227983 and rs6950826) and spectrin repeat containing, nuclear envelope 2 (SYNE2; rs8010699, rs4027405 and rs1890908) were associated with p21 expression. Moreover the haplotype block (rs2227983 and rs6950826, r2 = 0.378) in EGFR and the haplotype block in SYNE2 (rs8010699 was in strong LD with rs4027405 and rs1890908 (r2 = 0.91 and 0.70, respectively)) were identified and the haplotype A-G of EGFR and haplotype G-A-A of SYNE2 were significantly associated with p21 expression (P P = 0.001, P = 0.002). Our findings indicate that variants of EGFR and SYNE2 play an important role in p21 regulation and are associated with the clinical outcome of HBV-related HCC in a TP53-indenpdent manner.
Databáze: OpenAIRE
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