Priorities in stress research: a view from the U.S. National Institute of Mental Health
| Autor: | Janine M. Simmons, Julia L. Zehr, Lois Winsky, Joshua A. Gordon |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Physiology
Applied psychology Psychological intervention Fight-or-flight response 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Stress (linguistics) medicine Humans Set (psychology) National Institute of Mental Health (U.S.) Endocrine and Autonomic Systems Mental Disorders Stressor Cognition Mental illness medicine.disease Mental health United States 030227 psychiatry Psychiatry and Mental health Neuropsychology and Physiological Psychology Mental Health 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Stress (Amsterdam, Netherlands). 24(2) |
| ISSN: | 1607-8888 |
| Popis: | The mission of the National Institute of Mental Health is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. In consultation with a broad range of experts, the NIMH has identified a set of priorities for stress biology research aimed squarely at creating the basic and clinical knowledge bases for reducing and alleviating mental health burden across the lifespan. Here, we discuss these priority areas in stress biology research, which include: understanding the heterogeneity of stressors and outcomes; refining and expanding the experimental systems used to study stress and its effects; embracing and exploiting the complexity of the stress response; and prioritizing translational studies that seek to test mechanistic hypotheses in human beings. We emphasize the challenge of establishing mechanistic links across levels of analysis to explain how and when specific and diverse stressors lead to enduring changes in neural systems and produce lasting functional deficits in mental health relevant behaviors. An improved understanding of mechanisms underlying stress responses and the functional consequences of stress can and will speed translation from basic research to predictive markers of risk and to improved, personalized interventions for mental illness. |
| Databáze: | OpenAIRE |
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