Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?
| Autor: | Nusret Erdoğan, Sevinç Hallaç Keser, Yeşim Gürbüz, Nagehan Ozdemir Barisik, Sibel Sensu, Aylin Ege Gul |
|---|---|
| Přispěvatelé: | İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Sibel Şensu / 0000-0002-4607-780X, Nusret Erdoğan / 0000-0002-0333-8600, Gürbüz, Yeşim Saliha, Şensu, Sibel, Erdoğan, Nusret |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Proliferation index SDHB Pheochromocytoma Malignancy Gastroenterology Paraganglioma 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Pathological Adrenal gland business.industry General Medicine Thoracic Neoplasms medicine.disease Succinate Dehydrogenase 030104 developmental biology medicine.anatomical_structure Head and Neck Neoplasms 030220 oncology & carcinogenesis immunohistochemistry Immunohistochemistry business Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X 3418-1326 |
| DOI: | 10.31557/apjcp.2021.22.6.1721 |
| Popis: | Background: In this study, we aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. Methods: A total 114 PPGL cases (73 HNPGL, 15 TAPPGL and 27 Pheo belonging to 112 cases) are included. Immunohistochemically, SDHB and Ki-67 are investigated and malignancy risks are determined by PASS classification. Results are assessed statistically with chi-square test and p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|