Endogenous morhine:opening new doors for the treatment of pain and addiction
| Autor: | Massimo Guarna, Enrica Bianchi, Patrick Cadet, George B. Stefano, Stephen C. Pryor, Wei Zhu |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Clinical Biochemistry
Molecular Sequence Data Receptors Opioid mu Pain Context (language use) Pharmacology Nitric Oxide Mediator Drug tolerance Drug Discovery medicine Cyclic AMP Diabetes Mellitus Animals Humans Enzyme Inhibitors Receptor Cyclic GMP Injections Intraventricular Neurons Analgesics Base Sequence Morphine business.industry Brain Drug Tolerance Analgesics Opioid Opioid Signal transduction Opiate Nitric Oxide Synthase business Neuroscience Morphine Dependence medicine.drug Signal Transduction |
| Popis: | Nitric oxide (NO) signalling is at the forefront of intense research interest because its many effects remain controversial and seemingly contradictory. This paper examines its role as a potential mediator of pain and tolerance. Within this context discussion covers endogenous morphine, documenting its ability to be made in animal tissues, including nervous tissue, and in diverse animal phyla. Supporting morphine as an endogenous signalling molecule is the presence of the newly cloned mu3 opiate receptor subtype found in animal (including human) immune, vascular and neural tissues, which is coupled to NO release. Importantly, this mu opiate receptor subtype is morphine-selective and opioid peptide-insensitive, further highlighting the presence of morphinergic signalling coupled to NO release. These findings provide novel insights into pain and tolerance as morphinergic signalling exhibits many similarities with NO actions. Taken together, a select morphinergic signalling system utilising NO opens the gate for the development of novel pharmaceuticals and/or the use of old pharmaceuticals in new ways. |
| Databáze: | OpenAIRE |
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