Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study
| Autor: | Olaf B. Paulson, Stig Yndgaard, Szabolcs Lehel, Ling Feng, Hanne D. Hansen, Karine Madsen, Lars H. Pinborg, Anders Ettrup, Morten Ziebell, Agnete Dyssegaard, Claus Svarer, Gitte M. Knudsen |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Flumazenil Male 0106 biological sciences Time Factors Article Subject Sensory Receptor Cells Population lcsh:Medicine Simulation system Models Biological 01 natural sciences General Biochemistry Genetics and Molecular Biology Feedback Young Adult 03 medical and health sciences 0302 clinical medicine Bolus (medicine) 010608 biotechnology TRACER Journal Article medicine Humans Carbon Radioisotopes Infusions Intravenous education 11c flumazenil Mathematics education.field_of_study General Immunology and Microbiology medicine.diagnostic_test lcsh:R General Medicine Venous blood Middle Aged Clinical Trial Positron emission tomography Positron-Emission Tomography Metabolome Female 030217 neurology & neurosurgery Research Article Biomedical engineering medicine.drug |
| Zdroj: | Feng, L, Svarer, C, Madsen, K, Ziebell, M, Dyssegaard, A, Ettrup, A, Hansen, H D, Lehel, S, Yndgaard, S, Paulson, O B, Knudsen, G M & Pinborg, L H 2016, ' Design of Infusion Schemes for Neuroreceptor Imaging : Application to [(11)C]Flumazenil-PET Steady-State Study ', BioMed Research International, vol. 2016, 9132840 . https://doi.org/10.1155/2016/9132840 BioMed Research International BioMed Research International, Vol 2016 (2016) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2016/9132840 |
| Popis: | This study aims at developing a simulation system that predicts the optimal study design for attaining tracer steady-state conditions in brain and blood rapidly. Tracer kinetics was determined from bolus studies and used to construct the system. Subsequently, the system was used to design inputs for bolus infusion (BI) or programmed infusion (PI) experiments. Steady-state quantitative measurements can be made with one short scan and venous blood samples. TheGABAAreceptor ligand [C11]Flumazenil (FMZ) was chosen for this purpose, as it lacks a suitable reference region.Methods. Five bolus [C11]FMZ-PET scans were conducted, based on which population-based PI and BI schemes were designed and tested in five additional healthy subjects. The design of a PI was assisted by an offline feedback controller.Results. The system could reproduce the measurements in blood and brain. With PI, [C11]FMZ steady state was attained within 40 min, which was 8 min earlier than the optimal BI (B/I ratio = 55 min).Conclusions. The system can design both BI and PI schemes to attain steady state rapidly. For example, subjects can be [C11]FMZ-PET scanned after 40 min of tracer infusion for 40 min with venous sampling and a straight-forward quantification. This simulation toolbox is available for other PET-tracers. |
| Databáze: | OpenAIRE |
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