Solvent Properties of Water in Aqueous Solutions of Elastin-Like Polypeptide
| Autor: | Nolan B. Holland, Vladimir N. Uversky, Luisa A. Ferreira, James T. Cole, Christian Reichardt, Boris Y. Zaslavsky |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
osmolyte
Properties of water solvent dipolarity/polarizability Inorganic chemistry Trimethylamine Disaccharides Article Catalysis lcsh:Chemistry Inorganic Chemistry chemistry.chemical_compound phase-transition temperature Transition Temperature Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy Aqueous solution Chemistry Organic Chemistry Water elastin-like polypeptide General Medicine Trehalose Acceptor Elastin Computer Science Applications solvent properties Solvent hydrogen-bond donor acidity lcsh:Biology (General) lcsh:QD1-999 and hydrogen-bond acceptor basicity Osmolyte Solvents Salts Sorbitol Peptides Hydrophobic and Hydrophilic Interactions |
| Zdroj: | International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 13528-13547 (2015) International Journal of Molecular Sciences Volume 16 Issue 6 Pages 13528-13547 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms160613528 |
| Popis: | The phase-transition temperatures of an elastin-like polypeptide (ELP) with the (GVGVP)40 sequence and solvent dipolarity/polarizability, hydrogen-bond donor acidity, and hydrogen-bond acceptor basicity in its aqueous solutions were quantified in the absence and presence of different salts (Na2SO4, NaCl, NaClO4, and NaSCN) and various osmolytes (sucrose, sorbitol, trehalose, and trimethylamine N-oxide (TMAO)). All osmolytes decreased the ELP phase-transition temperature, whereas NaCl and Na2SO4 decreased, and NaSCN and NaClO4 increased it. The determined phase-transition temperatures may be described as a linear combination of the solvent's dipolarity/polarizability and hydrogen-bond donor acidity. The linear relationship established for the phase-transition temperature in the presence of salts differs quantitatively from that in the presence of osmolytes, in agreement with different (direct and indirect) mechanisms of the influence of salts and osmolytes on the ELP phase-transition temperature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|