Identification of a Novel Route of Iron Transcytosis across the Mammalian Blood-Brain Barrier
| Autor: | Jacqueline Tiong, Alexander R. Moise, Maki Ujiie, Brandie L. Walker, Wilfred A. Jefferies, Reinhard Gabathuler, Timothy Z. Vitalis, Iku Moroo, Delara Karkan |
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| Rok vydání: | 2003 |
| Předmět: |
Physiology
Iron Biology Blood–brain barrier Microcirculation Iodine Radioisotopes Mice Antigens Neoplasm Physiology (medical) medicine Animals Humans Molecular Biology chemistry.chemical_classification Iron Radioisotopes medicine.diagnostic_test Transferrin Brain Biological Transport Transporter medicine.disease Neoplasm Proteins Cell biology Mice Inbred C57BL medicine.anatomical_structure Transcytosis Biochemistry chemistry Blood-Brain Barrier Melanotransferrin Serum iron Alzheimer's disease Cardiology and Cardiovascular Medicine Melanoma-Specific Antigens |
| Zdroj: | Microcirculation. 10:457-462 |
| ISSN: | 1549-8719 1073-9688 |
| DOI: | 10.1038/sj.mn.7800213 |
| Popis: | Objective:This study was undertaken to assess the role of p97 (also known as melanotransferrin) in the transfer of iron into the brain, because the passage of most large molecules is limited by the presence of the blood–brain barrier, including that of the serum iron transporter transferrin. Methods:To study the function of the soluble form of p97, we followed the uptake of radioiodinated and 55Fe loaded p97 and transferrin by the brain during a 24-hour period. Results:We show that the soluble form of p97 has the ability to transcytose across the murine blood–brain barrier, and its transcytosis can be inhibited in a specific manner. We also provide evidence that p97 transports iron into the brain more efficiently than transferrin. Conclusions:These data support the idea that p97 is an important iron transporter across the blood–brain barrier in normal physiology and possibly in neurodegenerative diseases, such as Alzheimer disease, in which iron homeostasis in the brain becomes disrupted. Microcirculation... |
| Databáze: | OpenAIRE |
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