A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging

Autor: Bingbing Cheng, Jayanth Kandukuri, Yi Hong, Kytai T. Nguyen, Francis D'Souza, Baohong Yuan, Shuai Yu, Venugopal Bandi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Fluorescence-lifetime imaging microscopy
medicine.medical_specialty
Materials science
multi-color fluorescence imaging
deep-tissue fluorescence imaging
Contrast Media
ultrasound-switchable fluorescence imaging
01 natural sciences
Catalysis
Article
010309 optics
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
ultrasound imaging
0302 clinical medicine
0103 physical sciences
medicine
Image Processing
Computer-Assisted
Humans
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Ultrasonography
business.industry
Organic Chemistry
Ultrasound
Optical Imaging
General Medicine
dual-modality imaging
Ultrasound switchable fluorescence
Computer Science Applications
Molecular Imaging
Transducer
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
Imaging technology
Ultrasound imaging
Dual modality
Radiology
Molecular imaging
business
Biomedical engineering
Zdroj: International Journal of Molecular Sciences, Vol 18, Iss 2, p 323 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 2; Pages: 323
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90°-crossed ultrasound transducers with an overlapped focal region, while the US transducer (the third one) was positioned at the center of these two USF transducers. Thus, the axial resolution of USF is close to the lateral resolution, which allows a point-by-point USF scanning on the same plane as the US imaging. Both multi-color USF and ultrasound imaging of a tissue phantom were demonstrated.
Databáze: OpenAIRE
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