Successful Allogeneic Stem Cell Transplant in Pediatric Patients With Diminished Left Ventricular Ejection Fractions
| Autor: | Kent A. Robertson, Shannon M. Lyon, Jodi L. Skiles, David C. Delgado, Marcus S. Schamberger, John J. Parent, William S. Goebel |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty animal structures medicine.medical_treatment Cardiomyopathy Hematopoietic stem cell transplantation 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Transplantation Homologous Child Retrospective Studies Heart Failure Cardiotoxicity Ejection fraction business.industry Hematopoietic Stem Cell Transplantation Infant Hematology medicine.disease Prognosis Transplantation Leukemia Leukemia Myeloid Acute Oncology 030220 oncology & carcinogenesis Heart failure Pediatrics Perinatology and Child Health Cardiology Female Stem cell business 030215 immunology Follow-Up Studies |
| Zdroj: | Journal of pediatric hematology/oncology. 42(8) |
| ISSN: | 1536-3678 |
| Popis: | Chemotherapy-associated cardiotoxicity may delay or impair the ability to administer fully myeloablative chemotherapy for stem cell transplant in those with reduced left ventricular ejection fraction. Studies in adults have been inconsistent regarding the value of ejection fraction in predicting cardiotoxicity in the posttransplant period. Recent publications, however, have demonstrated successful stem cell transplantation in adults despite low ejection fractions. This case series highlights 2 pediatric patients who were successfully treated with stem cell transplantation without posttransplant cardiac complications, despite pretransplant ejection fractions of 38% and 29%. |
| Databáze: | OpenAIRE |
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