Predictive Factors Increasing the Risk of Radiation Toxicity in Patients with Early Breast Cancer
Autor: | Mohamed Hassan, Asmaa A Abdeltawab, Hanan Mostafa, Samia A. Ali |
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Rok vydání: | 2021 |
Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Breast Neoplasms 03 medical and health sciences Breast cancer 0302 clinical medicine Trastuzumab Internal medicine medicine risk factors Humans Prospective Studies normal tissue toxicity Radiation Injuries Adverse effect Prospective cohort study Mastectomy Aged Aged 80 and over Lung business.industry Letrozole General Medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Toxicity conventional radiotherapy Female Radiotherapy Adjuvant Dose Fractionation Radiation Radiodermatitis business Research Article Follow-Up Studies medicine.drug |
Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
ISSN: | 2476-762X |
Popis: | Objectives Radiation induces adverse events on healthy tissues which may be augmented by certain factors. This study aimed to assess patients; tumor and treatment-related factors which increase the risk of radiation-induced toxicity in breast cancer patients. Methods This prospective study included postmenopausal early breast cancer patients treated at the clinical oncology department, Assiut University, Egypt between January 2015 and December 2018. Patients treated with mastectomy followed by conventional radiotherapy (25x 2 Gy) and either concurrent or sequential letrozole. Acute and late radiation toxicity was scored according to EORTC/RTOG and risk factors were analyzed. Results A total of 75 patients were included in the study. After a median follow-up of 24 months, 12 patients had > grade 2 acute dermatitis, 5 patients had > grade 2 cardiac toxicity and 3 patients had > grade 2 lung toxicity. Multivariate analysis revealed that trastuzumab use was associated with a decrease risk of acute dermatitis (p= 0.01) but boost irradiation was significantly associated with increased risk of acute dermatitis (p= 0.01). Late toxicity > grade 2 was observed in 6 patients, 14 patients, and 2 patients for skin, heart, and lung respectively. Conclusion The use of boost irradiation was associated with increased risk of acute dermatitis, in the contrary; the use of trastuzumab seemed to be protective as observed in this study. |
Databáze: | OpenAIRE |
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