Diabetes induced by streptozotocin causes reduced Na-K ATPase in the brain
| Autor: | Thomas Leung, S. F. Leong |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty ATPase Central nervous system Hypothalamus Citrate (si)-Synthase Biology Biochemistry Hippocampus Diabetes Mellitus Experimental Cellular and Molecular Neuroscience chemistry.chemical_compound Thalamus Reference Values Lactate dehydrogenase Internal medicine Hexokinase medicine Citrate synthase Animals Na+/K+-ATPase Cerebral Cortex L-Lactate Dehydrogenase Brain Rats Inbred Strains General Medicine Streptozotocin Rats medicine.anatomical_structure Endocrinology chemistry Cerebral cortex Organ Specificity biology.protein Acetylcholinesterase Sodium-Potassium-Exchanging ATPase medicine.drug Brain Stem |
| Zdroj: | Neurochemical research. 16(10) |
| ISSN: | 0364-3190 |
| Popis: | Na−K ATPase activity in the brain decreased significantly after diabetes was induced with streptozotocin in rats. Largest decreases were observed in the hippocampus (−30%) and the cerebral cortex (−26%). Smaller decreases were observed in the thalamus (−13%), hypothalamus (−11%) and brain stem (−10%). Na−K ATPase activity in the striatum and the cerebellum were not significantly decreased. The varied decreases suggest that the regional variation of the enzyme is enhanced in the diabetic state. The enzymes of glucose metabolic pathway, namely hexokinase, lactate dehydrogenase and citrate synthase in the brain regions largely remained unchanged although increases in lactate dehydrogenase were observed in some regions. Acetylcholinesterase activity, a marker for the cholinergic system, remains unaltered in the brain during diabetes. The results are discussed with respect to the possible metabolic factors which alter the Na−K ATPase in the brain and its comparison with the peripheral nerve. |
| Databáze: | OpenAIRE |
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