The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
| Autor: | Kevin J. Tracey, Wei Li, Andrew E. Sama, Beatriz Rendon-Mitchell, Haichao Wang, Ping Wang, Huan Yang, Mala Ashok, Mahendar Ochani, Jianhua Li, Lihong Yang |
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| Předmět: |
Nutrition and Dietetics
Angelica sinensis biology Medicine (miscellaneous) Pharmacology HMGB1 biology.organism_classification medicine.disease Systemic inflammation Proinflammatory cytokine Sepsis In vivo Intensive care Immunology biology.protein medicine Tumor necrosis factor alpha medicine.symptom |
| Zdroj: | Scopus-Elsevier |
| Popis: | Despite recent advances in antibiotic therapy and intensive care, sepsis remains a widespread problem in critically ill patients. The high mortality from sepsis is in part mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., tumor necrosis factor, interleukin-1, and interferon-γ) and late [e.g., high mobility group box 1 protein (HMGB1)] proinflammatory cytokines. Our discovery of HMGB1 as a late mediator of lethal systemic inflammation has initiated a new field of investigation for the development of experimental therapeutics. A popular Chinese herb, Angelica sinensis (also known as Dang Gui or Dong Quai) has been used traditionally for treating women with gynecological disorders (such as dysmenorrheal and hot flashes). Here we examined the effect of Angelica sinensis extract on endotoxin-induced HMGB1 release in vitro, and explored its therapeutic potential in animal models of lethal endotoxemia and sepsis [induced by cecal ligation and puncture (CLP)] in vivo. We demonstrated that a low-molecular-weight ( |
| Databáze: | OpenAIRE |
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