WITHDRAWN—a resource for withdrawn and discontinued drugs
| Autor: | Janette Nickel, Christian Omieczynski, Robert Preissner, Vishal B. Siramshetty, Malgorzata N. Drwal, Bjoern-Oliver Gohlke |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Databases Pharmaceutical media_common.quotation_subject Biology Pharmacology 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit Polymorphism Single Nucleotide Signal pathway Safety-Based Drug Withdrawals 03 medical and health sciences Genetics medicine Lack of efficacy Humans Database Issue Drug Recalls Drug reaction Intensive care medicine Adverse effect media_common Internet Proteins 030104 developmental biology Pharmaceutical Preparations Drug recall Signal Transduction |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkv1192 |
| Popis: | Post-marketing drug withdrawals can be associated with various events, ranging from safety issues such as reported deaths or severe side-effects, to a multitude of non-safety problems including lack of efficacy, manufacturing, regulatory or business issues. During the last century, the majority of drugs voluntarily withdrawn from the market or prohibited by regulatory agencies was reported to be related to adverse drug reactions. Understanding the underlying mechanisms of toxicity is of utmost importance for current and future drug discovery. Here, we present WITHDRAWN, a resource for withdrawn and discontinued drugs publicly accessible at http://cheminfo.charite.de/withdrawn. Today, the database comprises 578 withdrawn or discontinued drugs, their structures, important physico-chemical properties, protein targets and relevant signaling pathways. A special focus of the database lies on the drugs withdrawn due to adverse reactions and toxic effects. For approximately one half of the drugs in the database, safety issues were identified as the main reason for withdrawal. Withdrawal reasons were extracted from the literature and manually classified into toxicity types representing adverse effects on different organs. A special feature of the database is the presence of multiple search options which will allow systematic analyses of withdrawn drugs and their mechanisms of toxicity. |
| Databáze: | OpenAIRE |
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