Tau protein is a potential biological marker for normal pressure hydrocephalus
| Autor: | Takashi Morihara, Hiroshi Mori, Tatsuo Mima, Yuko Koike, Hitoshi Tanimukai, Koreaki Mori, Yu Nakamura, Masatoshi Takeda, Kazuhisa Nakao, Ichiro Tsujio, Shinji Tagami, Toshihisa Tanaka, Ryouta Hashimoto, Takashi Kudo |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Tau protein Urinary incontinence tau Proteins Sensitivity and Specificity Central nervous system disease Cerebrospinal fluid Degenerative disease Normal pressure hydrocephalus Alzheimer Disease mental disorders medicine Dementia Humans Aged Aged 80 and over biology business.industry General Neuroscience Neurodegeneration General Medicine Middle Aged medicine.disease Hydrocephalus Normal Pressure Surgery Psychiatry and Mental health Neurology biology.protein Female Neurology (clinical) medicine.symptom business Biomarkers |
| Zdroj: | Psychiatry and clinical neurosciences. 54(2) |
| ISSN: | 1323-1316 |
| Popis: | A biological marker for normal pressure hydrocephalus (NPH) is beneficial for evaluation of its severity and of indications for shunt operation. Tau protein was initially considered as a biological marker in cerebrospinal fluid (CSF) from Alzheimer's patients. Recently, it has been demonstrated that degeneration in the brain causes elevation of tau in CSF. Therefore, the tau level in CSF from NPH patients was evaluated. Tau levels in CSF from NPH patients were significantly higher than that in controls. The tau levels were correlated with the severity of dementia, urinary incontinence, and gait disturbance in NPH. These results suggest that CSF tau may be useful as a biological marker for NPH to determine the level of neuronal degeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |