DNA methylation in infants with low and high body fatness

Autor: Elisabet Forsum, Patrick Müller, Signe Altmäe, Colm E Nestor, Pontus Henriksson, David Brodin, Antonio Lentini, Marie Löf
Přispěvatelé: [Henriksson,P, Löf,M] Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden. [Lentini,A, Nestor,CE] Crown Princess Victoria Children’s Hospital, and Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden. [Altmäe,S] Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain. [Altmäe,S] Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. [Brodin,D, Müller,P, Löf,M] Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. [Forsum,E] Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden., The study was funded by Formas (data collection) and a grant from Bo and Vera Ax:son Johnsons Foundation (data analysis) (both ML). CEN was supported by grants from the Swedish Research Council (2015–03495) and the Swedish Cancer Society (CAN 2017/625). SA was supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER) grants: RYC-2016-21199 and ENDORE SAF2017–87526. The funding body had no role in the design of the study, data collection, analysis and interpretation of data, writing of the manuscript and the decision to publish. Open Access funding provided by Linköping University Library.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
genetic structures
Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Birth Weight [Medical Subject Headings]
Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Fetal Development [Medical Subject Headings]
Buccal swab
Obesidad
Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings]
Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings]
Physiology
Índice de masa corporal
Body composition
Body Mass Index
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
0302 clinical medicine
Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylation [Medical Subject Headings]
Birth Weight
Peso al nacer
Body mass index
0303 health sciences
Persons::Persons::Age Groups::Infant [Medical Subject Headings]
Epigenetic
Anatomy::Tissues::Connective Tissue::Adipose Tissue [Medical Subject Headings]
Adipose Tissue
030220 oncology & carcinogenesis
DNA methylation
Body Composition
Anatomy::Tissues::Membranes::Mucous Membrane::Mouth Mucosa [Medical Subject Headings]
DNA microarray
Medical Genetics
psychological phenomena and processes
Biotechnology
Research Article
Metilación de ADN
lcsh:QH426-470
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Plethysmography [Medical Subject Headings]
Birth weight
lcsh:Biotechnology
Carbohydrate metabolism
Biology
Health outcomes
03 medical and health sciences
lcsh:TP248.13-248.65
Genetics
Humans
Epigenetics
Obesity
Composición corporal
030304 developmental biology
Medicinsk genetik
Body fatness
Mouth Mucosa
Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis
Genetic [Medical Subject Headings]
Infant
Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Body Composition [Medical Subject Headings]
DNA Methylation
lcsh:Genetics
Epigenómica
Persons::Persons::Parents [Medical Subject Headings]
Zdroj: BMC Genomics, Vol 21, Iss 1, Pp 1-9 (2020)
BMC Genomics
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
ISSN: 1471-2164
DOI: 10.1186/s12864-020-07169-7
Popis: The authors gratefully thank the parents and children that participated in the PATHOS study.
Background: Birth weight is determined by the interplay between infant genetics and the intrauterine environment and is associated with several health outcomes in later life. Many studies have reported an association between birth weight and DNA methylation in infants and suggest that altered epigenetics may underlie birthweight-associated health outcomes. However, birth weight is a relatively nonspecific measure of fetal growth and consists of fat mass and fat-free mass which may have different effects on health outcomes which motivates studies of infant body composition and DNA methylation. Here, we combined genome-wide DNA methylation profiling of buccal cells from 47 full-term one-week old infants with accurate measurements of infant fat mass and fat-free mass using air-displacement plethysmography. Results: No significant association was found between DNA methylation in infant buccal cells and infant body composition. Moreover, no association between infant DNA methylation and parental body composition or indicators of maternal glucose metabolism were found. Conclusions: Despite accurate measures of body composition, we did not identify any associations between infant body fatness and DNA methylation. These results are consistent with recent studies that generally have identified only weak associations between DNA methylation and birthweight. Although our results should be confirmed by additional larger studies, our findings may suggest that differences in DNA methylation between individuals with low and high body fatness may be established later in childhood.
Swedish Research Council Formas
Swedish Research Council 2015-03495
Swedish Cancer Society CAN 2017/625
Spanish Ministry of Economy, Industry and Competitiveness (MINE CO)
European Union (EU) RYC-2016-21199 ENDORE SAF2017-87526
Linkoping University Library
Bo and Vera Ax:son Johnsons Foundation
Databáze: OpenAIRE
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