Functional diversity of human vaginal APC subsets in directing T cell responses
| Autor: | Jacques Banchereau, Melissa Dullaers, Julien Gannevat, Jack Stecher, Muriel Boreham, Michael Carley, Dorothée Duluc, Esperanza Anguiano, Sandra Zurawski, Sangkon Oh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes T cell Cellular differentiation CD14 Immunology Lipopolysaccharide Receptors Antigen-Presenting Cells chemical and pharmacologic phenomena Biology CD8-Positive T-Lymphocytes Lymphocyte Activation Article Immunomodulation 03 medical and health sciences 0302 clinical medicine Immune system Antigen medicine Immunology and Allergy Humans dendritic cells Antigen-presenting cell mucosa Immunity Mucosal Th1-Th2 Balance Cells Cultured 030304 developmental biology Aged Aged 80 and over 0303 health sciences Macrophages Cell Differentiation Middle Aged 3. Good health medicine.anatomical_structure vagina T cell responses Langerhans Cells Female CD8 030215 immunology |
| Zdroj: | Mucosal immunology |
| ISSN: | 1935-3456 1933-0219 |
| Popis: | Human vaginal mucosa is the major entry site of sexually transmitted pathogens and thus has long been attractive as a site for mounting mucosal immunity. It is also known as a tolerogenic microenvironment. Here, we demonstrate that immune responses in the vagina can be orchestrated by the functional diversity of four major antigen-presenting cell (APC) subsets. Langerhans cells (LCs) and CD14(-) lamina propria-dendritic cells (LP-DCs) polarize CD4(+) and CD8(+) T cells toward T-helper type 2 (Th2), whereas CD14(+) LP-DCs and macrophages polarize CD4(+) T cells toward Th1. Both LCs and CD14(-) LP-DCs are potent inducers of Th22. Owing to their functional specialties and the different expression levels of pattern-recognition receptors on the APC subsets, microbial products do not bias them to elicit common types of immune responses (Th1 or Th2). To evoke desired types of adaptive immune responses in the human vagina, antigens may need to be targeted to proper APC subsets with right adjuvants. |
| Databáze: | OpenAIRE |
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