Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

Autor: Nicolas Chevalier, Bruno Vergès, Etienne Larger, L Bordier, Delphine Demarsy, Jean-François Thébaut, Dominique Seret-Bégué, Matthieu Wargny, Pierre-Antoine Gourraud, Coralie Amadou, Nathanaëlle Montanier, Myriam Lungo, P. Serusclat, Claude Chaumeil, Audrey Zabulon, Louis Potier, Jean-Baptiste Bonnet, Bertrand Cariou, Matthieu Pichelin, Pierre Gourdy, Anne-Marie Guedj, Nathalie Jeandidier, Jean-Philippe Le Berre, René Robert, Vincent Rigalleau, Ronan Roussel, O. Dupuy, Fritz-Line Velayoudom, Sarra Smati, Jean-François Gautier, Françoise Plat, Samy Hadjadj, Olivier Bourron, Camille Vatier, Patrice Winiszewski, Pierre-Yves Benhamou, Blandine Tramunt, Marie Dumas, Philippe Moulin, Patrice Darmon, Anna Flaus-Furmaniuk, B. Delenne
Přispěvatelé: unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Diabétologie - Maladies Métaboliques - Nutrition, CHU Toulouse [Toulouse], Centre Hospitalier Sud Francilien, Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Service de Diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Toulouse [Toulouse]-Hôpital de Rangueil, CH Evry-Corbeil, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de diabétologie [CHU Pitié-Salpétrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de recherche de l'institut du thorax (ITX-lab), Service Diabétologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Percentile
Home discharge
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
030204 cardiovascular system & hematology
0302 clinical medicine
Mechanical ventilation
Risk Factors
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Hospital Mortality
Aged
80 and over
Anticoagulant
Diabetes
Middle Aged
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Prognosis
Patient Discharge
3. Good health
Metformin
Hospitalization
Death
Female
France
Admission plasma glucose
medicine.drug
medicine.medical_specialty
Statin
HbA1c
Coronavirus disease 2019 (COVID-19)
medicine.drug_class
030209 endocrinology & metabolism
Article
Diabetes Complications
03 medical and health sciences
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Diabetes Mellitus
Humans
HbA(1c)
Aged
Retrospective Studies
business.industry
SARS-CoV-2
COVID-19
Retrospective cohort study
Length of Stay
medicine.disease
Respiration
Artificial
Discharge
business
Follow-Up Studies
Zdroj: Diabetologia
Diabetologia, Springer Verlag, 2021, 64 (4), pp.778-794. ⟨10.1007/s00125-020-05351-w⟩
Diabetologia, 2021, 64 (4), pp.778-794. ⟨10.1007/s00125-020-05351-w⟩
ISSN: 0012-186X
1432-0428
Popis: Aims/hypothesis This is an update of the results from the previous report of the CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). Methods The CORONADO initiative is a French nationwide multicentre study of patients with diabetes hospitalised for COVID-19 with a 28-day follow-up. The patients were screened after hospital admission from 10 March to 10 April 2020. We mainly focused on hospital discharge and death within 28 days. Results We included 2796 participants: 63.7% men, mean age 69.7 ± 13.2 years, median BMI (25th–75th percentile) 28.4 (25.0–32.4) kg/m2. Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of participants, respectively. Within 28 days, 1404 (50.2%; 95% CI 48.3%, 52.1%) were discharged from hospital with a median duration of hospital stay of 9 (5–14) days, while 577 participants died (20.6%; 95% CI 19.2%, 22.2%). In multivariable models, younger age, routine metformin therapy and longer symptom duration on admission were positively associated with discharge. History of microvascular complications, anticoagulant routine therapy, dyspnoea on admission, and higher aspartate aminotransferase, white cell count and C-reactive protein levels were associated with a reduced chance of discharge. Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors. Conclusions/interpretation In patients with diabetes hospitalised for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period. Trial registration Clinicaltrials.gov identifier: NCT04324736 Graphical abstract
Databáze: OpenAIRE
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