Human aflatoxin exposure in Uganda: Estimates from a subset of the 2011 Uganda AIDS indicator survey (UAIS)
| Autor: | Maya R. Sternberg, Michael E. Rybak, Edward K Mbidde, Abigael O Awuor, Johnni H. Daniel, Marc-Alain Widdowson, Nicholas C Zitomer |
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| Rok vydání: | 2020 |
| Předmět: |
Chronic exposure
Adult Male Aflatoxin Aflatoxin B1 Adolescent Health Toxicology and Mutagenesis 030231 tropical medicine 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Environmental health medicine Humans Mycotoxin 0105 earth and related environmental sciences Acquired Immunodeficiency Syndrome Blood Specimen Collection business.industry fungi technology industry and agriculture Public Health Environmental and Occupational Health Liver failure food and beverages General Chemistry General Medicine Environmental Exposure Middle Aged medicine.disease Health Surveys chemistry Human exposure Acute exposure Female Liver cancer business Biomarkers Food Science |
| Zdroj: | Food additivescontaminants. Part A, Chemistry, analysis, control, exposurerisk assessment. 38(1) |
| ISSN: | 1944-0057 |
| Popis: | Aflatoxins are carcinogenic mycotoxins that contaminate a variety of crops worldwide. Acute exposure can cause liver failure, and chronic exposure can lead to stunting in children and liver cancer in adults. We estimated aflatoxin exposure across Uganda by measuring a serum biomarker of aflatoxin exposure in a subsample from the 2011 Uganda AIDS Indicator Survey, a nationally representative survey of HIV prevalence, and examined its association with geographic, demographic, and socioeconomic variables. We analysed a subsample of 985 serum specimens selected among HIV-negative participants from 10 survey-defined geographic regions for serum aflatoxin B1-lysine (AFB1-lys) by use of isotope dilution LC-MS/MS and calculated results normalised to serum albumin. We used statistical techniques for censored data to estimate geometric means (GMs), standard deviations, and percentiles. We detected serum AFB1-lys in 71.7% of specimens (LOD = 0.5 pg/mg albumin). Unadjusted GM AFB1-lys (pg/mg albumin) was 1.33 (95% CI: 1.21-1.47). Serum AFB1-lys was higher in males (GM: 1.57; 95% CI: 1.38-1.80) vs. females (GM: 1.12; 95% CI: 0.97-1.30) ( |
| Databáze: | OpenAIRE |
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