The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder: results from the International Mood Disorders Collaborative Project
| Autor: | Danielle S. Cha, Mohammad Alsuwaidan, Yena Lee, Sidney H. Kennedy, Joanna K. Soczynska, David J. Muzina, Rodrigo B. Mansur, Roman S. Dale, Roger S. McIntyre, André F. Carvalho, Hanna O. Woldeyohannes, Maj Vinberg, Laura Ashley Gallaugher |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
business.industry Medicine (miscellaneous) medicine.disease Proxy (climate) 030227 psychiatry 03 medical and health sciences Distress 0302 clinical medicine Mood disorders Post-hoc analysis Severity of illness Marital status Medicine Major depressive disorder medicine.symptom business Psychiatry Major depressive episode 030217 neurology & neurosurgery Original Research |
| Zdroj: | Therapeutic Advances in Chronic Disease. 7:153-159 |
| ISSN: | 2040-6231 2040-6223 |
| Popis: | Objectives: The aim of the study was to evaluate the prevalence of and illness characteristics in adults with major depressive disorder (MDD) with anxious distress specifier (ADS) enrolled in the International Mood Disorders Collaborative Project, which is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Canada and the Cleveland Clinic, Cleveland, Ohio, USA. Methods: Data from participants who met criteria for a current major depressive episode as part of MDD ( n = 830) were included in this post hoc analysis. Diagnostic and Statistical Manual Version-5-defined ADS was operationalized as the presence of at least two out of three proxy items instead of two out of five specifiers. Results: A total of 464 individuals (i.e. 56%) met criteria for ADS. There were no between-group differences in sociodemographic variables (e.g. gender, employment, marital status). Greater severity of illness was observed in adults with ADS as evidenced by a higher number of hospitalizations, higher rates of suicidal ideation, greater depressive symptom severity, greater workplace impairment, decreased quality of life, and greater self-reported cognitive impairment. Conclusions: Our findings underscore the importance of evaluating ADS in adults with MDD as its presence identifies a subpopulation with greater illness-associated burden and hazards. |
| Databáze: | OpenAIRE |
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