Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science
| Autor: | Bryan M. Krause, Robert D. Sanders, Sean M. Grady, Caitlin A Murphy, Matthew I. Banks, Ziyad W. Sultan, Elizabeth R. Jaeckel |
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| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Adenosine medicine.medical_treatment Inflammation Adenosine receptor antagonist 03 medical and health sciences Mice Piroxicam 0302 clinical medicine 030202 anesthesiology Internal medicine Caffeine medicine Animals Humans Wakefulness Interleukin 6 Cerebral Cortex biology business.industry Age Factors Delirium Electroencephalography Electrophysiological Phenomena Mice Inbred C57BL Disease Models Animal Anesthesiology and Pain Medicine Endocrinology Cytokine Systemic administration biology.protein Prostaglandins Laboratory Investigation Cytokines medicine.symptom Hypoactivity business |
| Zdroj: | Br J Anaesth |
| ISSN: | 1471-6771 |
| Popis: | BACKGROUND: Novel preventive therapies are needed for postoperative delirium, which especially affects older patients. A mouse model is presented that captures inflammation-associated cortical slow wave activity (SWA) observed in patients, allowing exploration of the mechanistic role of prostaglandin-adenosine signalling. METHODS: EEG and cortical cytokine measurements (interleukin 6, monocyte chemoattractant protein-1) were obtained from adult and aged mice. Behaviour, SWA, and functional connectivity were assayed before and after systemic administration of lipopolysaccharide (LPS)+piroxicam (cyclooxygenase inhibitor) or LPS+caffeine (adenosine receptor antagonist). To avoid the confounder of inflammation-driven changes in movement which alter SWA and connectivity, electrophysiological recordings were classified as occurring during quiescence or movement, and propensity score matching was used to match distributions of movement magnitude between baseline and post-LPS administration. RESULTS: LPS produces increases in cortical cytokines and behavioural quiescence. In movement-matched data, LPS produces increases in SWA (likelihood-ratio test: χ(2)(4)=21.51, P |
| Databáze: | OpenAIRE |
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