Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution
Abstrakt: | We attached 2-aminoethylamino groups to allophenylnorstatine-containing plasmepsin (Plm) inhibitors and investigated SAR of the methyl or ethyl substitutions on the amino groups. Unexpectedly, compounds 22 (KNI-10743) and 25 (KNI-10742) exhibited extremely potent Plm II inhibitory activities (K(i) |
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ISSN: | 14643405 |