Immune Consequences of Endothelial Cells’ Activation and Dysfunction During Sepsis
| Autor: | Stéphanie Pons, Lara Zafrani, Marine Arnaud, Maud Loiselle, Eden Arrii, Elie Azoulay |
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| Rok vydání: | 2020 |
| Předmět: |
Multiple Organ Failure
Adaptive Immunity Critical Care and Intensive Care Medicine Systemic inflammation Sepsis 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Humans Endothelial dysfunction Innate immune system business.industry Endothelial Cells 030208 emergency & critical care medicine General Medicine medicine.disease Acquired immune system Immunity Innate Endothelial stem cell 030228 respiratory system Immunology Endothelium Vascular medicine.symptom business |
| Zdroj: | Critical Care Clinics. 36:401-413 |
| ISSN: | 0749-0704 |
| DOI: | 10.1016/j.ccc.2019.12.001 |
| Popis: | The vascular endothelium provides a direct interface between circulating blood cells and parenchymal cells. Thus, it has a key role in vasomotor tone regulation, primary hemostasis, vascular barrier, and immunity. In the case of systemic inflammation, endothelial cell (EC) activation initiates a powerful innate immune response to eliminate the pathogen. In some specific conditions, ECs may also contribute to the activation of adaptive immunity and the recruitment of antigen-specific lymphocytes. However, the loss of EC functions or an exaggerated activation of ECs during sepsis can lead to multiorgan failure. |
| Databáze: | OpenAIRE |
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