The value of hypercalciuria in patients with osteopenia versus osteoporosis
| Autor: | María Sierra Girón-Prieto, María del Carmen Cano-García, Salvador Arias-Santiago, Miguel Arrabal-Martin, Tomas de Haro-Muñoz, Miguel Angel Arrabal-Polo, Antonio Poyatos-Andujar |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Osteoporosis Hypercalciuria Osteocalcin 030232 urology & nephrology chemistry.chemical_element 030209 endocrinology & metabolism Urine Calcium Bone and Bones 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Aged Creatinine business.industry Middle Aged medicine.disease Urinary calcium Osteopenia Bone Diseases Metabolic Endocrinology Cross-Sectional Studies chemistry Female Densitometry business |
| Zdroj: | Urolithiasis. 45(3) |
| ISSN: | 2194-7236 |
| Popis: | The aim of this study was to analyze the presence of lithogenic metabolic factors in the blood and urine of patients with osteopenia versus osteoporosis. This is a cross-sectional study including 67 patients who were divided into two groups according to the presence of either osteopenia or osteoporosis as measured by bone densitometry: group 1—40 patients with osteopenia (22 men and 18 women) and group 2—27 patients with osteoporosis (13 men and 14 women). Metabolic studies were performed on the blood and urine; statistical analysis was performed comparing means and conducting linear correlation and multivariate analyses with SPSS. Statistical significance was considered to be p ≤ 0.05. The mean age of patients in group 1 was 52.9 ± 12.8 years versus 50.3 ± 11.4 in group 2; the difference was not statistically significant. In group 2, higher levels of osteocalcin, β-crosslaps, urinary calcium, fasting urine calcium/creatinine, 24 h urine calcium/creatinine and 24 h oxaluria were observed compared to group 1. In the multivariate analysis, only the β-crosslaps and urinary calcium were independently associated with osteoporosis. It would be advisable to determine the urinary calcium levels in patients with osteoporosis since altered levels may necessitate modifying the diagnostic and therapeutic approach to osteoporosis. |
| Databáze: | OpenAIRE |
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