Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
| Autor: | Audrey Sporrij, Leonard I. Zon, Julie R. Perlin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Stem cell factor Cell Communication Biology Article 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine Animals Humans Progenitor cell Genetics (clinical) Hematopoietic Stem Cell Transplantation Endothelial Cells Hematopoietic stem cell hemic and immune systems Hematopoietic Stem Cells Cell biology Endothelial stem cell Haematopoiesis 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Molecular Medicine Chemokines Stem cell Adult stem cell Homing (hematopoietic) |
| Zdroj: | Journal of Molecular Medicine. 95:809-819 |
| ISSN: | 1432-1440 0946-2716 |
| Popis: | Cells of the hematopoietic system undergo rapid turnover. Each day, humans require the production of about one hundred billion new blood cells for proper function. Hematopoietic stem cells (HSCs) are rare cells that reside in specialized niches and are required throughout life to produce specific progenitor cells that will replenish all blood lineages. There is, however, an incomplete understanding of the molecular and physical properties that regulate HSC migration, homing, engraftment, and maintenance in the niche. Endothelial cells (ECs) are intimately associated with HSCs throughout the life of the stem cell, from the specialized endothelial cells that give rise to HSCs, to the perivascular niche endothelial cells that regulate HSC homeostasis. Recent studies have dissected the unique molecular and physical properties of the endothelial cells in the HSC vascular niche and their role in HSC biology, which may be manipulated to enhance hematopoietic stem cell transplantation therapies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink