Glycosidase-inhibiting pyrrolidine alkaloids from Hyacinthoides non-scripta
| Autor: | Rhodri C. Griffiths, George W. J. Fleet, Alison A. Watson, David J. Harvey, Atsushi Kato, Eileen Lees, Stephen Dealler, Mark R. Wormald, Robert J. Nash, Andrew J. Cairns, Haruhisa Kizu, Naoki Asano |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
biology Liliaceae Stereochemistry Alkaloid Plant Science General Medicine Horticulture biology.organism_classification Biochemistry Pyrrolidine chemistry.chemical_compound Enzyme Hyacinthoides non-scripta Aglycone chemistry Glycoside hydrolase Hyacinthoides Molecular Biology |
| Popis: | The glycosidase-inhibiting pyrrolidine alkaloids (2 R ,3 R ,4 R ,5 R )-2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP), 2,5-dideoxy-2,5-imino- dl - glycero - d - manno -heptitol (homoDMDP), homoDMDP-7- O -apioside and 1,4-dideoxy-1,4-imino- d -arabinitol have been identified in the leaves of bluebells ( Hyacinthoides non-scripta ). HomoDMDP and homoDMDP-7- O -apioside are new natural products. Glycosidase inhibition by the aglycones is compared and could explain the symptoms of poisoning of livestock by bluebells. |
| Databáze: | OpenAIRE |
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