Seroprevalence of SARS-CoV-2-specific antibodies in the town of Ariano Irpino (Avellino, Campania, Italy): A population-based study
| Autor: | Antonio Pizzolante, Mario Capasso, Alessandro Perrella, Dario Bruzzese, Pellegrino Cerino, Luigi Atripaldi, Paolo A. Ascierto, Biancamaria Pierri, Palmiero Volzone, Gianfranco Brambilla, Massimo Zollo, Maria Triassi, Carlo Buonerba, Annachiara Coppola |
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| Přispěvatelé: | Cerino, P., Coppola, A., Volzone, P., Pizzolante, A., Pierri, B., Atripaldi, L., Zollo, M., Capasso, M., Ascierto, P. A., Triassi, M., Brambilla, G., Perrella, A., Bruzzese, D., Buonerba, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 Virology Ariano Irpino Population based study 03 medical and health sciences Specific antibody 030104 developmental biology 0302 clinical medicine Geography Seroprevalence epidemiology 030212 general & internal medicine Biotechnology Research Article |
| Zdroj: | Future Science OA |
| Popis: | The Italian municipality of Ariano Irpino (Avellino, Campania, Italy) was locked down by the regional authorities from March until April 2020 after several citizens tested positive for SARS coronavirus 2 (SARS-CoV-2). A serological mass screening campaign targeting the Ariano Irpino population using the Roche Cobas Elecsys anti-SARS-CoV-2 assay was organized by the Zoo-Prophylactic Institute of Southern Italy (Portici, Italy) and conducted in cooperation with the Local Health Unit (Azienda Sanitaria Locale – ASL – Avellino, Avellino, Italy), the Department of Public Health of University Federico II (Naples, Italy) and Department of Health Services of Azienda Ospedaliera dei Colli-Cotugno and Monaldi Hospital (Naples, Italy) in May 2020. A total of 13,218 asymptomatic individuals were reviewed in this analysis. A total of 738 citizens tested positive for anti-SARS-CoV-2 antibodies (398 females, 340 males). The overall prevalence in the sample was 5.6% (95% CI: 5.2–6.0). Among seropositive citizens, 101 cases tested positive on RT-PCR (0.76% of the overall population). Among citizens aged 14–18, 18–65 and >65 years, the seroprevalence was equal to 6.1 (95% CI: 4.1–8.7), 5.6 (95% CI: 5.1–6.1) and 4% (95% CI: 3.3–4.8), respectively. In the pediatric cohort ( Lay abstract A mass screening campaign targeting the Ariano Irpino population in Italy, including a total of 13,218 asymptomatic individuals, showed that 5.6% of the tested individuals had antibodies against the virus responsible for COVID-19 in the blood. Among citizens aged 65 years, the proportion of positive individuals was equal to 13, 6.1, 5.6 and 4%, respectively. These asymptomatic individuals, who were identified by a simple blood draw using an inexpensive test (costing only a few euros), could inadvertently spread the infection. A serological-based screening strategy could therefore be a cost-effective public health intervention. |
| Databáze: | OpenAIRE |
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