Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men
| Autor: | Margareth de Oliveira Pereira, Elisangela Samartin Pegas Pereira, Maria Carolina Fidelis, Fernanda Sayuri Ota, Raquel Fávaro, Lúcia Arruda, Elvira Cancio Assumpção, Adilson Costa, Stephanie Selma Barros Langen, Eva Nydal Abildgaard, Felipe Borba Calixto dos Santos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
food.ingredient
integumentary system Vitamin C Traditional medicine business.industry Dermatology Bioinformatics Skin Aging supplements Skin hydration antioxidants food Clinical Cosmetic and Investigational Dermatology Oral supplements Grape seed extract Medicine skin hydration business Original Research dermal density |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology |
| ISSN: | 1178-7015 |
| Popis: | Adilson Costa,1,2 Elisangela Samartin Pegas Pereira,1 Elvira Cancio Assumpção,1 Felipe Borba Calixto dos Santos,1 Fernanda Sayuri Ota,1 Margareth de Oliveira Pereira,1 Maria Carolina Fidelis,1 Raquel Fávaro,1 Stephanie Selma Barros Langen,1 Lúcia Helena Favaro de Arruda,1 Eva Nydal Abildgaard3 1Department of Dermatology, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil; 2KOLderma Clinical Trials Institute, Campinas, São Paulo, Brazil; 3Pfizer Consumer Healthcare, Nutritional Sciences, Copenhagen, Denmark Background: Skin aging is a natural process that may be aggravated by environmental factors. Topical products are the conventional means to combat aging; however, the use of oral supplements is on the rise to assist in the management of aged skin.Objective: The purpose of this study was to assess the effects and safety of an oral supplement containing (per tablet) marine protein (105 mg), vitamin C (27 mg), grape seed extract (13.75 mg), zinc (2 mg), and tomato extract (14.38 mg) in the improvement of skin aging in men.Methods: This single-center, open-label, quasi-experimental clinical study enrolled 47 male subjects, aged 30–45 years, with phototypes I–IV on the Fitzpatrick scale. Subjects received two tablets of the oral supplement for 180 consecutive days. Each subject served as their own control. Clinical assessments were made by medical personnel and by the subjects, respectively. Objective assessments were carried out through pH measurements, sebumetry, corneometry, ultrasound scanning, skin biopsies, and photographic images.Results: Forty-one subjects (87%) completed the study. Clinical improvements on both investigator- and subject-rated outcomes were found for the following parameters: erythema, hydration, radiance, and overall appearance (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|