Marine Algicolous Endophytic Fungi - A Promising Drug Resource of the Era
| Autor: | Jayesh Puthumana, Jeonghoon Han, Rosamma Philip, Jae-Seong Lee, Neema Job, Manomi Sarasan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antifungal Antifungal Agents medicine.drug_class Secondary Metabolism Antineoplastic Agents Secondary metabolite Biology Applied Microbiology and Biotechnology Plant use of endophytic fungi in defense 03 medical and health sciences chemistry.chemical_compound Drug Discovery Botany Drug resource Endophytes medicine Symbiosis Biological Products Bioprospecting Fungi General Medicine Seaweed Antimicrobial Bioactive compound 030104 developmental biology chemistry Biotechnology medicine.drug |
| Zdroj: | Journal of Microbiology and Biotechnology. 27:1039-1052 |
| ISSN: | 1738-8872 1017-7825 |
| DOI: | 10.4014/jmb.1701.01036 |
| Popis: | Endophytic fungi have currently been acknowledged as the most promising source of bioactive compounds for drug discovery, and considerable progress has been made in exploring their diversity, species richness, and bioprospecting. Fungal endophytes from unique environmental settings offer a pool of potentially useful medicinal entities. Owing to the constant stresses imposed on macroalgae by marine environments, it is believed that algae and their associated endophytic symbionts represent a good source of structurally diverse bioactive secondary metabolites. Despite the proven significance of active metabolites of algal endophytes, little have been exploited. This review highlights the latest discoveries in algicolous endophytic research, with particular focus on the bioactive metabolites from algal endophytes. Compounds are classified according to their reported biological activities, like anticancer, antibacterial, antifungal, and antioxidant properties. Present experimental evidence suggests that a majority of the bioactive metabolites were reported from Phaeophyceae followed by Rhodophyceae and Chlorophyceae. An intensive search for newer and more effective bioactive metabolites has generated a treasure trove of publications, and this review partially covers the literature published up to 2016. |
| Databáze: | OpenAIRE |
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