The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease
| Autor: | Valeria Vasciaveo, Michela Guglielmotto, Debora Monteleone, Giusi Manassero, Elena Tamagno, Massimo Tabaton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
autophagy Aβ oligomers Tau protein Peptide Disease Review tau protein Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Alzheimer Disease Animals Humans chemistry.chemical_classification Amyloid beta-Peptides biology General Neuroscience Autophagy General Medicine Peptide Fragments Psychiatry and Mental health Clinical Psychology 030104 developmental biology Monomer chemistry Aβ monomers Alzheimer’s disease biology.protein Biomarker (medicine) Geriatrics and Gerontology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease |
| Popis: | Amyloid-β (Aβ) has been proposed as a biomarker and a drug target for the therapy of Alzheimer's disease (AD). The neurotoxic entity and relevance of each conformational form of Aβ to AD pathology is still under debate; Aβ oligomers are considered the major killer form of the peptide whereas monomers have been proposed to be involved in physiological process. Here we reviewed some different effects mediated by monomers and oligomers on mechanisms involved in AD pathogenesis such as autophagy and tau aggregation. Data reported in this review demonstrate that Aβ monomers could have a major role in sustaining the pathogenesis of AD and that AD therapy should be focused not only in the removal of oligomers but also of monomers. |
| Databáze: | OpenAIRE |
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