Prostate zonal anatomy correlates with the detection of prostate cancer on multiparametric magnetic resonance imaging/ultrasound fusion–targeted biopsy in patients with a solitary PI-RADS v2–scored lesion
| Autor: | Kevin A. Nguyen, Preston C. Sprenkle, Jeffrey C. Weinreb, Angelique Levi, Steffen Huber, Jamil Syed, Cayce Nawaf, Peter A. Humphrey, Ansh M. Bhagat, Peter G. Schulam |
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| Rok vydání: | 2017 |
| Předmět: |
Image-Guided Biopsy
Male medicine.medical_specialty Prostate biopsy Urology 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Biopsy medicine Humans Multiparametric Magnetic Resonance Imaging Ultrasonography medicine.diagnostic_test business.industry Prostatic Neoplasms Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging PI-RADS medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Radiology medicine.symptom business |
| Zdroj: | Urologic Oncology: Seminars and Original Investigations. 35:542.e19-542.e24 |
| ISSN: | 1078-1439 |
| Popis: | Purpose To evaluate the positive predictive value (PPV) of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) assessment method in patients with a single suspicious finding on prostate multiparametric magnetic resonance imaging (mpMRI). Patients and methods A total of 176 patients underwent MRI/ultrasound fusion–targeted prostate biopsy after the detection of a single suspicious finding on mpMRI. The PPV for cancer detection was determined based on PI-RADS v2 assessment score and location. Results Fusion biopsy detected prostate cancer in 60.2% of patients. Of these patients, 69.8% had Gleason score (GS) ≥7 prostate cancer. Targeted biopsy detected 90.5% of all GS≥7 prostate cancer. The PPV for GS≥7 detection of PI-RADS v2 category 5 (P5) and category 4 (P4) lesions was 70.2% and 37.7%, respectively. This increased to 88% and 38.5% for P5 and P4 lesions in the peripheral zone (PZ), respectively. Targeted biopsy did not miss GS≥7 disease compared with systematic biopsy in P5 lesions in the PZ and transition zone. Conclusion The PPV of PI-RADS v2 for prostate cancer in patients with a single lesion on mpMRI is dependent on PI-RADS assessment category and location. The highest PPV was for a P5 lesion in the PZ. |
| Databáze: | OpenAIRE |
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