Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation
| Autor: | José Ramón González-Juanatey, David de Gonzalo-Calvo, Marinela Couselo-Seijas, Laila González-Melchor, Aurora Baluja, F J García-Seara, Sonia Eiras, Moisés Rodríguez-Mañero, V. Llorente-Cortés, Jose M. Guerra, David Vilades, A Rozados, Xesús Alberte Fernández-López, Rubén Leta, Jl. Martinez-Sande, J N López-Canoa |
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| Přispěvatelé: | Instituto de Salud Carlos III, European Commission, Sociedade Galega de Cardioloxía, Ministerio de Economía y Competitividad (España), Red de Investigación Cardiovascular (España) |
| Rok vydání: | 2021 |
| Předmět: |
Leptin
Male medicine.medical_specialty medicine.medical_treatment Adipose tissue Adipokine Catheter ablation 030204 cardiovascular system & hematology Ablation Fatty Acid-Binding Proteins Gastroenterology Pathogenesis Fatty acid-binding protein 4 03 medical and health sciences 0302 clinical medicine Adipokines Recurrence Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Sex Characteristics business.industry Gender Atrial fibrillation medicine.disease Confidence interval Treatment Outcome Cohort Catheter Ablation Female Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname EUROPACE r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| ISSN: | 1099-5129 |
| Popis: | Aims: Adiposity plays a key role in the pathogenesis of atrial fibrillation (AF). Our aim was to study the sex differences in adipokines levels according to AF burden. Methods and results: Two independent cohorts of patients were studied: (i) consecutive patients with AF undergoing catheter ablation (n = 217) and (ii) a control group (n = 105). (i) Adipokines, oxidative stress, indirect autonomic markers, and leucocytes mRNA levels were analysed; (ii) correlation between biomarkers was explored with heatmaps and Kendall correlation coefficients; and (iii) logistic regression and random forest model were used to determine predictors of AF recurrence after ablation. Our results showed that: (i) fatty acid-binding protein 4 (FABP4) and leptin levels were higher in women than in men in both cohorts (P < 0.01). In women, FABP4 levels were higher on AF cohort (20 ± 14 control, 29 ± 18 paroxysmal AF and 31 ± 17 ng/mL persistent AF; P < 0.01). In men, leptin levels were lower on AF cohort (22 ± 15 control, 13 ± 16 paroxysmal AF and 13 ± 11 ng/mL persistent AF; P < 0.01). (ii) In female with paroxysmal AF, there was a lower acetylcholinesterase and higher carbonic anhydrase levels with respect to men (P < 0.05). (iii) Adipokines have an important role on discriminate AF recurrence after ablation. In persistent AF, FABP4 was the best predictor of recurrence after ablation (1.067, 95% confidence interval 1-1.14; P = 0.046). Conclusion: The major finding of the present study is the sex-based differences of FABP4 and leptin levels according to AF burden. These adipokines are associated with oxidative stress, inflammatory and autonomic indirect markers, indicating that they may play a role in AF perpetuation. This study was supported by projects (PI16/01282 and PI18/01584) integrated in the Plan Estatal de I+D+I 2016–2019 and cofounded by ISCIII-Subdirección General de Evaluación y Fomento de la Investigación del Fondo Europeo de Desarrollo Regional (FEDER). J.N.L.-C. and M.R.-M. were a recipient of a Sociedade Galega de Cardioloxía (SOGACAR) research grant. D.d.G.-C. was a recipient of a Juan de la Cierva-Incorporación grant from the Ministry of Science Innovation and Universities (IJCI-2016-29393). CIBER Cardiovascular (CB16/11/00403 to V.Ll.-C. and D.d.G.-C.) is a project from Carlos III Health Institute. |
| Databáze: | OpenAIRE |
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