Endometriosis accelerates synchronization of early embryo cell divisions but does not change morphokinetic dynamics in endometriosis patients

Autor:	Martina Hörmann-Kröpfl, Michael Schenk, Gregor Weiss, Julia M. Kröpfl
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Embryology Blastomeres Medical Implants Maternal Health Endometriosis Oocyte Retrieval 0302 clinical medicine Animal Cells Pregnancy Medicine and Health Sciences Cell Cycle and Cell Division 030219 obstetrics & reproductive medicine Multidisciplinary Cell Cycle Obstetrics and Gynecology Embryo Embryo transfer Cell Processes OVA embryonic structures Medicine Engineering and Technology Female Embryo Development Cellular Types Live birth Live Birth Research Article Biotechnology Adult medicine.medical_specialty animal structures Reproductive Techniques Assisted Science Reproductive medicine Embryonic Development Bioengineering Time-Lapse Imaging Andrology 03 medical and health sciences Population Metrics medicine Humans Retrospective Studies Fetus Population Biology business.industry Embryogenesis Embryos Biology and Life Sciences Blastomere Cell Biology Birth Rates medicine.disease Embryo Transfer 030104 developmental biology Germ Cells Case-Control Studies Oocytes Women's Health Medical Devices and Equipment business Developmental Biology
Zdroj:	PLoS ONE PLoS ONE, Vol 14, Iss 8, p e0220529 (2019) PLoS ONE, 14 (8)
ISSN:	1932-6203
Popis:	Objective The pathology of endometriosis and its impact on embryo development is still a black box in reproductive medicine. In this time-lapse study we investigated the influence of endometriosis on morphokinetic parameters of embryo development, taking variables of dynamic monitoring into account. Furthermore we evaluated reproductive medicine treatment outcome such as fetal heartbeat and live birth rate. Methods 1148 embryos (control: n = 596, endometriosis: n = 552) were retrospectively analyzed. Patients were stimulated with GnRH antagonist protocol. After fertilization, embryos were incubated in a time-lapse system (EmbryoScope). Results The mixed-model analysis revealed a significant main effect of time (p PLoS ONE, 14 (8) ISSN:1932-6203
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7949b59a88339a9e3590fc6289df77 http://europepmc.org/articles/PMC6675061 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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