Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
Autor: | Sheryl E. Arambula, Meghan E. Rebuli, Brian Horman, Heather B. Patisaul, Allison L. Phillips, Heather M. Stapleton, Kylie R. Baldwin |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Placenta Science Physiology 010501 environmental sciences Bioinformatics 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound Sex Factors Pregnancy medicine Animals Endocrine system Rats Wistar Flame Retardants 0105 earth and related environmental sciences Analysis of Variance Multidisciplinary Behavior Animal Dose-Response Relationship Drug Molecular Structure business.industry Organophosphate Age Factors medicine.disease Rats Dose–response relationship 030104 developmental biology medicine.anatomical_structure chemistry Toxicity Gestation Medicine Female Analysis of variance business |
Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Firemaster® 550 (FM 550) is a commercial flame retardant mixture of brominated and organophosphate compounds applied to polyurethane foam used in furniture and baby products. Due to widespread human exposure, and structural similarities with known endocrine disruptors, concerns have been raised regarding possible toxicity. We previously reported evidence of sex specific behavioral effects in rats resulting from developmental exposure. The present study expands upon this prior finding by testing for a greater range of behavioral effects, and measuring the accumulation of FM 550 compounds in placental tissue. Wistar rat dams were orally exposed to FM 550 during gestation (0, 300 or 1000 µg/day; GD 9 – 18) for placental measurements or perinatally (0, 100, 300 or 1000 µg/day; GD 9 – PND 21) to assess activity and anxiety-like behaviors. Placental accumulation was dose dependent, and in some cases sex specific, with the brominated components reaching the highest levels. Behavioral changes were predominantly associated with a loss or reversal of sex differences in activity and anxiety-like behaviors. These findings demonstrate that environmental chemicals may sex-dependently accumulate in the placenta. That sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficits is a possibility that merits further investigation. |
Databáze: | OpenAIRE |
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