Influence of surface roughness on silicone rubber voice prostheses on in vitro biofilm formation and clinical lifetime in laryngectomised patients
| Autor: | B.F.A.M. van der Laan, L. Basil, H. C. Van Der Mei, M. Waters, Kevin J. D. A. Buijssen, M. A. Duits, Henk J. Busscher, J. J. H. Oosterhof |
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| Přispěvatelé: | Man, Biomaterials and Microbes (MBM), Personalized Healthcare Technology (PHT), Damage and Repair in Cancer Development and Cancer Treatment (DARE) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Glottis medicine.medical_specialty Surface Properties Dentistry TOPOGRAPHY ADHESION Prosthesis Design Silicone rubber biofilm Clinical study 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Silicone medicine Surface roughness Humans University medical 030223 otorhinolaryngology Laryngeal Neoplasms laryngectomy Aged Aged 80 and over Hypopharyngeal Neoplasms business.industry Biofilm technology industry and agriculture 030206 dentistry Middle Aged Prosthesis Failure Surgery Smooth surface Otorhinolaryngology chemistry Biofilms surface roughness Silicone Elastomers silicone Larynx Artificial business surface modification RESISTANCE |
| Zdroj: | Clinical Otolaryngology, 42(6), 1235-1240. Wiley |
| ISSN: | 0307-7772 |
| Popis: | Objectives Evaluation of the influence of a smooth surface moulding technique of silicone rubber indwelling voice prostheses on in vitro biofilm formation and analysis of the clinical in situ lifetime. Design Biofilm formation on smooth and Groningen ultra-low resistance (URL) prostheses was studied in an artificial throat model. The clinical lifetime of smooth voice prostheses were compared to the previous lifetime of URL by counting the number of replacements in a consecutive 6 months period in the same patient. Participants: Eleven laryngectomized patients in follow up who required frequent replacement of their voice prostheses. Settings Tertiary University Medical Center. Results Use of a smoother mould and less viscous silicone rubber yielded a decrease in surface roughness from 46 nm to 8 nm, and was accompanied by a 40% reduction in the prevalence of bacteria and yeast in in vitro formed biofilms. Clinically, the lifetime was significantly (p < 0.005) increased by a factor of 2.1. Conclusions This combined in vitro and clinical study suggests that the choice of material and in particular its surface finishing, may be determining factors with respect to the clinical lifetime of silicone rubber implants and devices failing due to biofilm formation. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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